What are the factors causing inaccuracy in capsule filling?
Equipment: stability, speed, sticking, powder-toss etc.
Material: properties of API, density, porosity, fluidity etc.
Technique: granular size, evenness, moisture etc.
Environment: temperature, humidity, static etc.
Human: skill, responsibility, proficiency etc.
Troubled by the problem of inaccuracy, what do we do?
Sampling by hand? Or import an equipment to inspect one by one? What do we want from manual sampling inspection?To record data during process so as to locate the problem.
To monitor the quality and keep filling under control.
To ensure the capsule filling machine operating stably.
To find and solve abnormal phenomena in time.
But is it really effective to sample capsules by hand?
With low efficiency, lagging monitoring, possibly missing a filling symptom
Authenticity, validity and integrality of sampling data are hard to be ensured as evidences.
There is a time gap between the process of sampling, weighing, recording and judging and discovering an issue.
Even the filling problem is found, faulty products cannot be isolated immediately.
The source of problem is not identified timely and the checking process leads to a continuous bad situation.
Above reasons explain the filling inaccuracy when manual sampling exists in every pharmaceutical company.
